Gomesin, a peptideproduced by the spiderAcanthoscurria gomesiana, is a potentanticryptococcalagentthatacts in synergism with£uconazole
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چکیده
Gomesin, a peptideproduced by the spiderAcanthoscurria gomesiana, is a potentanticryptococcalagentthatacts in synergism with£uconazole Fabiane M. Barbosa, Sirlei Daffre, Rosa A. Maldonado, Antonio Miranda, Leonardo Nimrichter & Marcio L. Rodrigues Laboratório de Estudos Integrados em Bioquı́mica Microbiana, Departamento de Microbiologia Geral, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo-SP, Brazil; Department of Biological Sciences; University of Texas at El Paso, El Paso, Texas, USA; and Departamento de Biofı́sica, Universidade Federal de São Paulo, Rua Três de Maio, São Paulo-SP, Brazil
منابع مشابه
Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family.
We have purified a small size antimicrobial peptide, named gomesin, from the hemocytes of the unchallenged tarantula spider Acanthoscurria gomesiana. Gomesin has a molecular mass of 2270.4 Da, with 18 amino acids, including a pyroglutamic acid as the N terminus, a C-terminal arginine alpha-amide, and four cysteine residues forming two disulfide bridges. This peptide shows marked sequence simila...
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Due to the cytotoxic effect of antimicrobial peptides (AMP) against several microorganism and tumor cells has been proposed their association with the immune system. However, just a few reports have shown this relationship. In this study, mice were treated with gomesin, a β-hairpin AMP that exhibit high cytotoxicity against bacterial and tumor cells. Different effects in the immune system were ...
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Some antimicrobial peptides have a broad spectrum of action against many different kinds of microorganisms. Gomesin and protegrin-1 are examples of such antimicrobial peptides, and they were studied by molecular dynamics in this research. Both have a beta-hairpin conformation stabilized by two disulfide bridges and are active against gram-positive and gram-negative bacteria, as well as fungi. I...
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تاریخ انتشار 2007